SnapShot: Transcription Regulation: Pausing
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چکیده
منابع مشابه
SnapShot: Transcription Regulation: Pausing
Productive elongation Modes of P-TEFb Recruitment: TFs (e.g., MYC, NF-κB) Mediator (Med26 subunit or Cdk8 module) Acetylated histones and Brd4 Other elongation factors as part of the superelongation complex CRE DNA-binding transcription factors (TFs) associate with cis-regulatory elements (CRE) to promote assembly of the PIC. TFs can stimulate PIC formation directly through interactions with th...
متن کاملSnapShot: Transcription Elongation
Transcription elongation is a key regulatory step in gene expression that is controlled by many proteins, and mechanisms, ranging from RNA Polymerase II pausing to cotranscriptional histone modifications.
متن کاملComparison of pausing during transcription and replication.
Pausing during the transcription of MDV-1 cDNA by Escherichia coli RNA polymerase was compared with pausing during the replication of MDV-1 RNA by Q beta replicase. MDV-1 RNA is able to form many strong hairpin structures, and Q beta replicase pauses after the synthesis of each [Mills et al. (1978) Cell 15, 541-550]. Although the transcripts were virtually identical to MDV-1 RNA, the locations ...
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In bacteria, RNA polymerase (RNAP) initiates transcription by synthesizing short transcripts that are either released or extended to allow RNAP to escape from the promoter. The mechanism of initial transcription is unclear due to the presence of transient intermediates and molecular heterogeneity. Here, we studied initial transcription on a lac promoter using single-molecule fluorescence observ...
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FOXM1 (12p13.33) GLI1, doxorubicin, NRAS, fulvestrant, butyric acid, FGF7, CDKN1A, YY1, MSA, vitamin D3, TNFSF11, IL6, CDC2 CDC25B, CENPA, AURKB, CCNA2, CCNF, CENPB, BIRC5, CCNB1, CDKN1A, ESR1, ADAM17, GLB1 Controls progression into S phase; regulates genes required for mitotic entry; liver development. Reduced hepatoblast and cardiomyocyte mitosis, ventricular hypoplasia. Die perinatally. Upre...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2013.04.011